Tiopronin is a US Food and Drug Administration (FDA)-approved drug for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
Tiopronin is a US Food and Drug Administration (FDA)-approved drug for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Zhichao Zhou et. Al. Cytochrome P-450 2C9 exerts a vasoconstrictor influence on coronary resistance vessels in swine at rest and during exercise. American Journal of Physiology - Heart and Circulatory Physiology, 302(8), H1747-H1755 (2012).
[2] Effect of N-2-mercaptopropionyl glycine on exercise-induced cardiac adaptations Nelson, M.J. et al. Am. J. Physiol. 300, R993-R1000, (2011).
分子式 C5H9NO3S |
分子量 163.19 |
CAS号 1953-02-2 |
储存方式 -20 ℃长期冷藏储存。冰袋运输 |
溶剂(常温) |
DMSO 32 mg/mL |
Water 32 mg/mL |
Ethanol 32 mg/mL |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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