生物活性

Cimetidine(Tagamet), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.

体外研究

体内研究

激酶实验

细胞实验

动物实验

不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

参考文献

[1]Robert B. Cotton,et al. Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome P450 mechanism independent of H2 receptor antagonism. J Mol Cell Cardiol. Author manuscript; available in PMC 2014 Jun 1. Published in final edited form as: J Mol Cell Cardiol. 2013 Jun; 59: 86–94. Published online 2013 Feb 27. doi: 10.1016/j.yjmcc.2013.02.010.
[2] JA Sprowl,et al. Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther. Author manuscript; available in PMC 2014 May 1. Published in final edited form as: Clin Pharmacol Ther. 2013 Nov; 94(5): 585–592. Published online 2013 Jul 17. doi: 10.1038/clpt.2013.145.
[3] Juliana Y Koshimizu,et al. NF-kB overexpression and decreased immunoexpression of AR in the muscular layer is related to structural damages and apoptosis in cimetidine-treated rat vas deferens. Reprod Biol Endocrinol. 2013; 11: 29. Published online 2013 Apr 9. doi: 10.1186/1477-7827-11-29.

体内溶解度

Clinical Trial Information ( data from http://clinicaltrials.gov )

注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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