Chenodeoxycholic acid is a naturally occurring human bile acid.
Chenodeoxycholic acid is a naturally occurring human bile acid.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Ryan D. Jones,et al. Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice. Steroids. Author manuscript; available in PMC 2016 Jan 1. Published in final edited form as: Steroids. 2015 Jan; 0: 87–95. Published online 2014 Nov 28. doi: 10.1016/j.steroids.2014.11.002.
[2] Soon-Jung Park,et al. Direct Effect of Chenodeoxycholic Acid on Differentiation of Mouse Embryonic Stem Cells Cultured under Feeder-Free Culture Conditions. Biomed Res Int. 2013; 2013: 375076. Published online 2012 Dec 29. doi: 10.1155/2013/375076.
分子式 C24H40O4 |
分子量 392.57 |
CAS号 474-25-9 |
储存方式 -20 ℃长期冷藏储存。冰袋运输 |
溶剂(常温) |
DMSO 200 mM |
Water <1 mg/mL |
Ethanol 200 mM |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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