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Isradipine

Dynacirc

Isradipine is a 2,4-dihydropyridine selective agonist and calcium channel protein inhibitor( IC50 = 34±8 μM). Research has indicated that Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.

目录号
EY2269
EY2269
EY2269
EY2269
纯度
99.16%
99.16%
99.16%
99.16%
规格
1 mg
5 mg
10 mg
50 mg
原价
172
345
550
1960
售价
172
345
550
1960
库存
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现货
现货
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  • 生物活性

    Isradipine is a 2,4-dihydropyridine selective agonist and calcium channel protein inhibitor( IC50 = 34±8 μM). Research has indicated that Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] E Ilijic,et al.The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson’s disease. Published in final edited form as: Neurobiol Dis. 2011 Aug; 43(2): 364–371. Published online 2011 Apr 16. doi: 10.1016/j.nbd.2011.04.007.
    [2] Philip F. Copenhaver,et al. A translational continuum of model systems for evaluating treatment strategies in Alzheimer’s disease: isradipine as a candidate drug. Ramaker, Tracy L. Swanson, Teri L. Wadsworth, Doris Kretzschmar, Randall L. Woltjer, Joseph F. Quinn. Dis Model Mech. 2011 Sep; 4(5): 634–648. Published online 2011 May 19. doi: 10.1242/dmm.006841.

    分子式
    C19H21N3O5    		 分子量
    371.39    		 CAS号
    75695-93-1    		 储存方式
    -20 ℃长期冷藏储存。冰袋运输
    溶剂（常温）
    		 DMSO
    >70 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    >70 mg/mL

    体内溶解度
    2% DMSO+Corn oil 10mg/mL

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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