Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.
Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Tatsuomi Shiga,et al. A Single Neonatal Injection of Ethinyl Estradiol Impairs Passive Avoidance Learning and Reduces Expression of Estrogen Receptor α in the Hippocampus and Cortex of Adult Female Rats. PLoS One. 2016; 11(1): e0146136. Published online 2016 Jan 7. doi: 10.1371/journal.pone.0146136.
[2] Melissa A Yates,et al. GPR30, but not estrogen receptor-α, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol. BMC Immunol. 2010; 11: 20. Published online 2010 Apr 19. doi: 10.1186/1471-2172-11-20.
[3] Sherry A. Ferguson,et al. Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats. Toxicol Sci. 2014 Aug 1; 140(2): 374–392. Published online 2014 Aug 2. doi: 10.1093/toxsci/kfu077.
分子式 C20H24O2 |
分子量 296.4 |
CAS号 57-63-6 |
储存方式 -20 ℃长期冷藏储存。冰袋运输 |
溶剂(常温) |
DMSO 59 mg/mL |
Water <1 mg/mL |
Ethanol 59 mg/mL |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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