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Ethinyl Estradiol

Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

目录号
EY2262
EY2262
EY2262
纯度
98.57%
98.57%
98.57%
规格
50 mg
100 mg
500 mg
原价
263
415
790
售价
263
415
790
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Tatsuomi Shiga,et al. A Single Neonatal Injection of Ethinyl Estradiol Impairs Passive Avoidance Learning and Reduces Expression of Estrogen Receptor α in the Hippocampus and Cortex of Adult Female Rats. PLoS One. 2016; 11(1): e0146136. Published online 2016 Jan 7. doi: 10.1371/journal.pone.0146136.
    [2] Melissa A Yates,et al. GPR30, but not estrogen receptor-α, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol. BMC Immunol. 2010; 11: 20. Published online 2010 Apr 19. doi: 10.1186/1471-2172-11-20.
    [3] Sherry A. Ferguson,et al. Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats. Toxicol Sci. 2014 Aug 1; 140(2): 374–392. Published online 2014 Aug 2. doi: 10.1093/toxsci/kfu077.

    分子式
    C20H24O2
    分子量
    296.4
    CAS号
    57-63-6
    储存方式
    -20 ℃长期冷藏储存。冰袋运输
    溶剂(常温)
    DMSO
    59 mg/mL
    Water
    <1 mg/mL
    Ethanol
    59 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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