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Methimazole

Tapazole,Northyx

Methimazole(Tapazole, Northyx) is an antithyroid medicine. It is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

目录号
EY2256
EY2256
纯度
99.37%
99.37%
规格
100 mg
500 mg
原价
275
480
售价
275
480
库存
现货
现货
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  • 生物活性

    Methimazole(Tapazole, Northyx) is an antithyroid medicine. It is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Yousuke Nakashimo,et al. Expression of transient receptor potential channel vanilloid (TRPV) 1–4, melastin (TRPM) 5 and 8, and ankyrin (TRPA1) in the normal and methimazole-treated mouse olfactory epithelium. Acta Otolaryngol. 2010 Nov; 130(11): 1278–1286. Published online 2010 Jun 30. doi: 10.3109/00016489.2010.489573.
    [2] Anuja Alapati,et al. Simple modifications to Methimazole that enhance its inhibitory effect on Tumor Necrosis Factor-α-induced Vascular Cell Adhesion Molecule-1 expression by human endothelial cells. Eur J Pharmacol. Author manuscript; available in PMC 2016 Sep 12. Published in final edited form as: Eur J Pharmacol. 2015 Mar 15; 751: 59–66. Published online 2015 Jan 29. doi: 10.1016/j.ejphar.2015.01.032.

    分子式
    C4H6N2S    		 分子量
    114.17    		 CAS号
    60-56-0    		 储存方式
    -20 ℃长期冷藏储存。冰袋运输
    溶剂（常温）
    		 DMSO
    23 mg/mL    		 Water
    23 mg/mL    		 Ethanol
    23 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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