Doripenem Hydrate is an ultra-broad spectrum injectable antibiotic.
Doripenem Hydrate is an ultra-broad spectrum injectable antibiotic.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Mohd H. Abdul-Aziz,et al. Population Pharmacokinetics of Doripenem in Critically Ill Patients with Sepsis in a Malaysian Intensive Care Unit. Antimicrob Agents Chemother. 2016 Jan; 60(1): 206–214. Prepublished online 2015 Oct 19. Published online 2015 Dec 31. doi: 10.1128/AAC.01543-15.
[2] M. G. Vossen,et al. Doripenem Treatment during Continuous Renal Replacement Therapy. Antimicrob Agents Chemother. 2016 Mar; 60(3): 1687–1694. Prepublished online 2015 Dec 28. Published online 2016 Feb 26. doi: 10.1128/AAC.01801-15.
分子式 C15H26N4O7S2 |
分子量 438.52 |
CAS号 364622-82-2 |
储存方式 -20 ℃长期冷藏储存。冰袋运输 |
溶剂(常温) |
DMSO 40 mg/mL |
Water 28 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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