Home > 暂无记录 Signal Pathway > NF-κB

NF-κB


NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.

  • Tizanidine HCl EY2245

    Tizanidine HCl is a skeletal muscle relaxant. It is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

    More

  • Asenapine EY2232

    Asenapine inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

    More

  • PBTZ169 EY2413

    PBTZ169 is a new drug candicate that inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043.

    More

  • ICI 118，551 hydrochloride EI1327

    ICI 118，551 hydrochloride是高选择性 β2 拮抗剂。

    More

  • Idazoxan hydrochloride EI1332

    Idazoxan hydrochloride是α2 拮抗剂。 也是I2 配体。

    More

  • Tizanidine HCl EY2245

    Tizanidine HCl is a skeletal muscle relaxant. It is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

    More

  • Asenapine EY2232

    Asenapine inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

    More

  • PBTZ169 EY2413

    PBTZ169 is a new drug candicate that inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043.

    More

  • ICI 118，551 hydrochloride EI1327

    ICI 118，551 hydrochloride是高选择性 β2 拮抗剂。

    More

  • Idazoxan hydrochloride EI1332

    Idazoxan hydrochloride是α2 拮抗剂。 也是I2 配体。

    More
    • Current page7, Total Pages28, Total Record140 First Prev 56789 Next Last Goto
More