Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience is recognized as a branch of biology.
A neuron is an electrically excitable cell that processes and transmits information through electrical and chemical signals. These signals between neurons occur via synapses, specialized connections with other cells. Neurons can connect to each other to form neural networks. Neurons are the core components of the brain and spinal cord of the central nervous system (CNS), and of the ganglia of the peripheral nervous system (PNS).
All neurons are electrically excitable, maintaining voltage gradients across their membranes by means of metabolically driven ion pumps, which combine with ion channels embedded in the membrane to generate intracellular-versus-extracellular concentration differences of ions such as sodium, potassium, chloride, and calcium. Changes in the cross-membrane voltage can alter the function of voltage-dependent ion channels. If the voltage changes by a large enough amount, an all-or-none electrochemical pulse called an action potential is generated, which travels rapidly along the cell's axon, and activates synaptic connections with other cells when it arrives.
Avagacestat是口服生物有效的,选择性的γ-分泌酶抑制剂,作用于Aβ40和Aβ42时,IC50分别为0.3 nM和0.27 nM,比作用于Notch选择性高193倍。
MoreTMP269是IIa型HDAC选择性抑制剂,对于HDAC4、5、7、9的IC50分别为126、80、36、9nM。相对于1型HDAC有20-400倍的选择性。
MoreRG2833(RGFP109)是可通过血脑屏障的HDAC抑制剂,对HDAC1和HDAC3的IC50分别为60nM和50nM。
MorePomalidomide能抑制LPS诱导的TNF-α释放,IC50为13 nM。
MoreMGCD0103 (Mocetinostat)是HDAC抑制剂,对HDAC 1,HDAC 2和HDAC 3的IC50分别为0.15,0.29和1.66 μM。
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