Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience is recognized as a branch of biology.
A neuron is an electrically excitable cell that processes and transmits information through electrical and chemical signals. These signals between neurons occur via synapses, specialized connections with other cells. Neurons can connect to each other to form neural networks. Neurons are the core components of the brain and spinal cord of the central nervous system (CNS), and of the ganglia of the peripheral nervous system (PNS).
All neurons are electrically excitable, maintaining voltage gradients across their membranes by means of metabolically driven ion pumps, which combine with ion channels embedded in the membrane to generate intracellular-versus-extracellular concentration differences of ions such as sodium, potassium, chloride, and calcium. Changes in the cross-membrane voltage can alter the function of voltage-dependent ion channels. If the voltage changes by a large enough amount, an all-or-none electrochemical pulse called an action potential is generated, which travels rapidly along the cell's axon, and activates synaptic connections with other cells when it arrives.
Droxinostat是一种选择性的HDAC抑制剂,最有效作用于HDACs 6和8,IC50为2.47μM和1.46 μM,比作用于HDAC3选择性高8倍,对HDAC1, 2, 4, 5, 7, 9,和10没有抑制作用。
MoreCUDC-907是I型PI3K和I、II型HDA的双重C抑制剂,对PI3Kα/β/δ的IC50分别为19/54/39 nM,对HDAC1/2/3/10的IC50分别为1.7/5.0/1.8/2.8 nM。
MoreResminostat是HDAC1/3/6抑制剂,IC50为43到72 nM,而对HDAC8的IC50为877 nM。
MoreNexturastat A是HDAC6高度选择性抑制剂,IC50为5 nM,对其它HDAC亚型无抑制性。
MoreCUDC-101是HDAC,EGFR和HER2抑制剂,IC50分别为4.4,2.4和15.7 nM。
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