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Metabolism


Metabolism is the set of life-sustaining chemical transformations within the cells of living organisms. The three main purposes of metabolism are the conversion of food/fuel to energy to run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. 

  • LY2228820 EY0979

    LY2228820是p38MAPK抑制剂，对p38αMAPK和p38βMAPK的IC50分别为7 nM和3 nM。

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  • HO-3867 EY0955

    HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.

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  • WP1066 EY0931

    WP1066是一种新型JAK2和STAT3抑制剂，IC50分别为2.30 μM和2.43 μM；对JAK2， STAT3， STAT5和ERK1/2具有抑制活性，但不抑制JAK1和JAK3。

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  • YM155 EY0758

    YM155 (Sepantronium Bromide)是一种有效的survivin抑制剂，通过抑制Survivin启动子活性而发挥作用，IC50为0.54 nM；对SV40启动子活性抑制作用不显著，对Survivin与XIAP相互作用抑制效果微弱。Phase 1/2。

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  • Olanzapine EY0717

    Olanzapine是5-HT2和D2受体高亲和性拮抗剂。

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