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Metabolism


Metabolism is the set of life-sustaining chemical transformations within the cells of living organisms. The three main purposes of metabolism are the conversion of food/fuel to energy to run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. 

  • Stattic EY1827

    Stattic是第一个非肽类小分子，有效抑制STAT3激活和核易位，IC50为5.1 μM，高选择性作用于STAT1。

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  • RS-127445 EY1668

    RS-127445(MT 500)是5-HT2B受体拮抗剂，pKi和pIC50分别为9.5和10.4。

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  • Losmapimod EY1329

    Losmapimod一种是口服活性的p38 MAPK抑制剂，对p38α和p38β的pKi为8.1和7.6。

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  • Ketanserin EY1297

    Ketanserin 是一种特异性的5-HT2A 5-羟色胺受体拮抗剂，作用于大鼠和人5-HT2A，Ki为2.5 nM。

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  • PH-797804 EY1076

    PH-797804是一种新型吡啶酮抑制剂，作用于p38α，IC50为26 nM；比作用于p38β选择性高4倍以上，不抑制JNK2。

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