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MAPK


MAPK(A mitogen-activated protein kinase)  is a type of protein kinase that is specific to the amino acids serine, threonine, and tyrosine . MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.

  • LDE225 EY1212

    LDE225 (NVP-LDE225,Erismodegib)是一种Smoothened(Smo)拮抗剂，抑制Hedgehog (Hh)信号通路，IC50分别为1.3 nM (小鼠)和2.5 nM(人)。

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  • Cyclopamine EY1171

    Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂，作用于Smoothened (Smo)，IC50为46 nM。

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  • Elaiophylin EY1094

    Elaiophylin大环内脂类抗菌素，作用于恶性疟原虫K1a 和布氏布锥虫GUTat 3.1 品系，具有抗原生动物活性，IC50分别为370 ng/mL和460 ng/mL。

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  • Taladegib EY1618

    LY2940680能结合Smoothened (Smo)受体，并抑制Hedgehog (Hh)信号传导。

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  • Glasdegib EY1249

    PF-04449913是口服生物相容性的smoothened抑制剂，IC50为5 nM，是hedgehog通路抑制剂。

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