Endocrinology is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones.
The endocrine system consists of several glands, all in different parts of the body, that secrete hormones directly into the blood rather than into a duct system. Hormones have many different functions and modes of action; one hormone may have several effects on different target organs, and, conversely, one target organ may be affected by more than one hormone.
IWP-2抑制Wnt信号和分泌,IC50为27 nM,选择性抑制Porcn介导的Wnt棕榈酰化,一般不影响Wnt/β-catenin,且对Wnt刺激的细胞反应没有影响。
MoreNutlin-3b是MDM2/p53抑制剂,IC50为13.6 μM。
MoreMI-773是一种高效的选择性MDM2抑制剂, 与MDM2结合, Ki值为0.88 nM.
MoreIWP L6是高活性Porcn抑制剂,EC50为0.5 nM。
MoreYH239-EE是YH239的乙酯形式,是p53-MDM2的拮抗剂、凋亡诱导剂。
More