Home > 暂无记录 Signal Pathway > Endocrinology & Hormones

Endocrinology & Hormones


Endocrinology is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. 

The endocrine system consists of several glands, all in different parts of the body, that secrete hormones directly into the blood rather than into a duct system. Hormones have many different functions and modes of action; one hormone may have several effects on different target organs, and, conversely, one target organ may be affected by more than one hormone.

  • XAV-939 EY1720

    XAV-939能够通过抑制tankyrase1/2而选择性抑制Wnt/β-catenin介导的转录,IC50分别为11 nM/4 nM,对CRE, NF-κB和TGF-β无抑制作用。

    More
  • RITA EY1570

    RITA (NSC 652287)诱导DNA-蛋白质和DNA-DNA交联,检测不到DNA单链断裂,通过靶向作用于p53,也抑制MDM2-p53相互作用。

    More
  • ICG-001 EY1452

    ICG-001拮抗Wnt/β-catenin/TCF介导的转录,并特异性结合到启动子结合蛋白(CBP),IC50为3 μM,但不能结合到相关的转录共激活因子p300上。

    More
  • Wnt-C59 EY1294

    Wnt-C59 (C59)是一种PORCN抑制剂,作用于Wnt3A-调节的多聚TCF结合位点驱动的荧光素酶的激活,IC50为74 pM。

    More
  • KY02111 EY1087

    KY02111抑制Wnt信号,促进hPSCs分化为心肌细胞,可能对APC和GSK3β的下游起作用。

    More
  • Current page3, Total Pages6, Total Record27 First Prev 12345 Next Last Goto