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Ricolinostat (ACY-1215) is an oral, first-in-class, selective inhibitor of HDAC6, and inhibits tubulin deacetylase. Rocilinostat (ACY-1215)是高效HDAC6抑制剂，IC50为5 nM，比对HDAC1/2/3的抑制性高10倍以上，对HDAC8有微弱活性，对HDAC4/5/7/9/11，Sirtuin1和Sirtuin2活性最低。
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Calcitriol, the active form of vitamin D, is known for its anticancer properties including induction of apoptosis as well as the inhibition of angiogenesis and metastasis.Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol )是维生素D3的活性代谢物，能激活维生素D受体（VDR）。
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Nicotinamide (NAM), an amide form of niacin (vitamin B3), is a water-soluble and noncompetitive inhibitor of the deacetylation reaction catalyzed by Sirtuins and it acts as constituent of the enzyme cofactors NAD and NADP. Nicotinamide (Vitamin B3) 是一种水溶性维生素，是NAD 和 NADP的活性成分，也是一种sirtuins抑制剂。
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PF-562271, which is a potent ATP-competitive Pyk2/FAK dual inhibitor, has completed phase I clinical trial and is considered to be a promising drug for patients with solid tumors. PF-562271是一种有效的，ATP竞争性的，可逆的FAK抑制剂，IC50为1.5 nM，作用于Pyk2比作用于FAK选择性低10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。
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MK-1775, a potent and selective ATP-competitive inhibitor of WEE1, is cytotoxic across a broad panel of tumor cell lines and induces DNA double-strand breaks. MK-1775是Wee1选择性抑制剂，IC50为5.2 nM，能干扰G2期DNA损伤检查。
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