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Ponesimod is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator.
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Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases.
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Siponimod is a potent and selective S1P1 receptor agonist with EC50 of 0.4 nM; >10,000 fold potency for S1P3.
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Fusidate Sodium is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.
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Torezolid phosphate is a novel oxazolidinone for gram-positive infections, has an IC50 of 8.7 μM and 5.7 μM for monoamine oxidase (MAO)-A and MAO-B, respectively.
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