Home > 暂无记录 Signal Pathway > NF-κB

NF-κB


NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.

  • Xylometazoline HCl EY2862

    Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Phase 4.

    More

  • Brexpiprazole EY2722

    Brexpiprazole是D2多巴胺部分激动剂。

    More

  • Atipamezole EY2730

    Atipamezole is an alpha-adrenoceptor antagonist with high affinity and selectivity for the alpha 2-receptor.

    More

  • Labetalol HCl EY2589

    Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.

    More

  • Carteolol HCl EY2584

    Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.

    More

  • Xylometazoline HCl EY2862

    Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Phase 4.

    More

  • Brexpiprazole EY2722

    Brexpiprazole是D2多巴胺部分激动剂。

    More

  • Atipamezole EY2730

    Atipamezole is an alpha-adrenoceptor antagonist with high affinity and selectivity for the alpha 2-receptor.

    More

  • Labetalol HCl EY2589

    Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.

    More

  • Carteolol HCl EY2584

    Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.

    More
    • Current page3, Total Pages29, Total Record141 First Prev 12345 Next Last Goto
More