Home > 暂无记录 Signal Pathway > NF-κB

NF-κB


NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.

  • AT7867 EY0267

    AT7867是一种有效的，ATP竞争性的Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 n/47 nM和85 nM/20 nM，对AGC激酶家族以外几乎没有抑制活性。

    More

  • L-755,507 EY2011

    L-755,507 enhances CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs). L-755,507 is also a very potent and selective β3-AR adrenergic receptor partial agonist, selective over both β1-AR and β2-AR adrenoceptor binding.

    More

  • BTZ043 EY1806

    BTZ043是DprE1的抑制剂，它在结核杆菌中有低浓度的抗菌活性。

    More

  • Epinephrine Bitartrate EY1770

    L-Epinephrine Bitartrate是α和β肾上腺素受体刺激剂，是一种激素和神经递质。

    More

  • Ivabradine HCl EY1724

    Ivabradine是新的If抑制剂，IC50为2.9μM。

    More

  • AT7867 EY0267

    AT7867是一种有效的，ATP竞争性的Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 n/47 nM和85 nM/20 nM，对AGC激酶家族以外几乎没有抑制活性。

    More

  • L-755,507 EY2011

    L-755,507 enhances CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs). L-755,507 is also a very potent and selective β3-AR adrenergic receptor partial agonist, selective over both β1-AR and β2-AR adrenoceptor binding.

    More

  • BTZ043 EY1806

    BTZ043是DprE1的抑制剂，它在结核杆菌中有低浓度的抗菌活性。

    More

  • Epinephrine Bitartrate EY1770

    L-Epinephrine Bitartrate是α和β肾上腺素受体刺激剂，是一种激素和神经递质。

    More

  • Ivabradine HCl EY1724

    Ivabradine是新的If抑制剂，IC50为2.9μM。

    More
    • Current page22, Total Pages29, Total Record141 First Prev 2021222324 Next Last Goto
More