NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.
UK 14,304是α2 激动剂。
MoreTerazosin hydrochloride是α1和α2B 拮抗剂 (α1 > α2B)。 口服有效。
MoreTC 1698 dihydrochloride是α7选择性激动剂。
MoreTamsulosin hydrochloride是选择性α1A 拮抗剂。
MoreSR 58611A hydrochloride是β3 激动剂, 显示抗焦虑,抗抑郁作用(anxiolytic,antidepressant activities)。
MoreUK 14,304是α2 激动剂。
MoreTerazosin hydrochloride是α1和α2B 拮抗剂 (α1 > α2B)。 口服有效。
MoreTC 1698 dihydrochloride是α7选择性激动剂。
MoreTamsulosin hydrochloride是选择性α1A 拮抗剂。
MoreSR 58611A hydrochloride是β3 激动剂, 显示抗焦虑,抗抑郁作用(anxiolytic,antidepressant activities)。
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