NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.
GSK-961081是一种新的muscarinic受体拮抗剂和β2-肾上腺素受体激动剂。
MoreZinterol hydrochloride是选择性 β2 激动剂。
MoreXamoterol hemifumarate是β1 选择性部分激动剂。
MoreWB 4101 hydrochloride是α1A 拮抗剂。
MoreGSK-961081是一种新的muscarinic受体拮抗剂和β2-肾上腺素受体激动剂。
MoreZinterol hydrochloride是选择性 β2 激动剂。
MoreXamoterol hemifumarate是β1 选择性部分激动剂。
MoreWB 4101 hydrochloride是α1A 拮抗剂。
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