NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.
(S)-(-)-Propranolol hydrochloride是β 拮抗剂。Propranolol活性更好的的对映体之一。
More(S)-(-)-Pindolol是β3 部分 激动剂。Pindolol的对映体之一。
More(S)-(-)-Atenolol是β1-拮抗剂。Atenolol的活性异构体。
More(RS)-Atenolol是β1 拮抗剂。
More(R)-(-)-Niguldipine hydrochloride是α1 拮抗剂, L-type Ca2+ 通道阻断剂。Niguldipine hydrochloride的对映体之一。
More(S)-(-)-Propranolol hydrochloride是β 拮抗剂。Propranolol活性更好的的对映体之一。
More(S)-(-)-Pindolol是β3 部分 激动剂。Pindolol的对映体之一。
More(S)-(-)-Atenolol是β1-拮抗剂。Atenolol的活性异构体。
More(RS)-Atenolol是β1 拮抗剂。
More(R)-(-)-Niguldipine hydrochloride是α1 拮抗剂, L-type Ca2+ 通道阻断剂。Niguldipine hydrochloride的对映体之一。
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