Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience is recognized as a branch of biology.
A neuron is an electrically excitable cell that processes and transmits information through electrical and chemical signals. These signals between neurons occur via synapses, specialized connections with other cells. Neurons can connect to each other to form neural networks. Neurons are the core components of the brain and spinal cord of the central nervous system (CNS), and of the ganglia of the peripheral nervous system (PNS).
All neurons are electrically excitable, maintaining voltage gradients across their membranes by means of metabolically driven ion pumps, which combine with ion channels embedded in the membrane to generate intracellular-versus-extracellular concentration differences of ions such as sodium, potassium, chloride, and calcium. Changes in the cross-membrane voltage can alter the function of voltage-dependent ion channels. If the voltage changes by a large enough amount, an all-or-none electrochemical pulse called an action potential is generated, which travels rapidly along the cell's axon, and activates synaptic connections with other cells when it arrives.
EHop-016是Rac GTPase高效选择性抑制剂,在MDA-MB-435细胞中IC50值1.1uM。
MoreThalidomide 能抑制由bFGF或VEGF诱导的体内血管生成。
MoreScriptaid是HDAC抑制剂,相对于H3对乙酰化的H4效果更明显。
MoreRomidepsin (FK228, Depsipeptide)是一种HDAC1和HDAC2抑制剂,IC50分别为36 nM和47 nM。
MoreBelinostat是一种新型的HDAC抑制剂,IC50为27 nM,对抵抗Cisplatin的肿瘤有效。
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