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MAPK


MAPK(A mitogen-activated protein kinase)  is a type of protein kinase that is specific to the amino acids serine, threonine, and tyrosine . MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.

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    PF 5274857 hydrochloride是高亲和性，选择性 Smoothened (Smo) 受体拮抗剂。

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  • MRT 10 EI1786

    MRT 10是Smoothened (Smo) 拮抗剂。

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  • IHR 1 EI1339

    IHR 1是活性的 Smo(Smoothened) 拮抗剂。

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  • Chloroquine Phosphate EY1843

    Chloroquine Phosphate是一种4-氨基喹啉的抗疟疾和抗风湿抑制剂。

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  • Purmorphamine EY1769

    Purmorphamine与Smo拮抗剂竞争性结合到Smoothened，并激活Smoothened，IC50约为1.5 μM，也诱导成骨细胞分化，EC50为1μM。

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