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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • T0070907 EY0423

    T0070907 (T007), a potent and selective PPARγ inhibitor, can reduce α and β tubulin proteins in some cancer cell lines. T0070907是一种选择性的PPARγ抑制剂，IC50为1 nM，比作用于PPARα和PPARδ选择性高800倍以上。

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  • Ponatinib EY0427

    Ponatinib (AP24534)是一种新型有效的作用于Abl， PDGFRα， VEGFR2， FGFR1和Src的多靶点抑制剂， IC50分别为0.37 nM， 1.1 nM， 1.5 nM， 2.2 nM和5.4 nM。

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  • Fluvastatin Sodium EY0440

    Fluvastatin sodium (XU62-320) is a potent, water-soluble inhibitor of HMG-CoA reductase, widely used as a cholesterol- lowering drug. Fluvastatin sodium 是HMG-CoA还原酶竞争性抑制剂。

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  • WY-14643 EY0400

    WY-14643 (Pirinixic Acid), a moderate dual PPARα/γ activator, inhibits neuroinflammation and oxidative stress, and also possesses antidepressive activities. WY-14643 (Pirinixic Acid)是一种有效的过氧化物酶体增殖子和PPARα激活剂，EC50为1.5 μM。

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  • Tranylcypromine HCl EY0405

    Tranylcypromine hydrochloride is a racemic mixture of (±)-Trans-2-phenylcyclopropyl-1-amine (TCP, tPCPA) · HCl that covalently inhibits the LSD and MAO enzymes. Tranylcypromine (2-PCPA) HCl是一种非选择性的不可逆的单胺氧化酶(MAO)抑制剂，用作抗抑郁药和抗焦虑药。

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