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Pazopanib, an orally available multi-kinase inhibitor of VEGFR, PDGFR, KIT, FGFR, as well as RAF, shows potent activity against a variety of solid tumors. Pazopanib是多重靶点抑制剂，对VEGFR1， VEGFR2，VEGFR3，PDGFR，FGFR，c-Kit 和 c-Fms的IC50分别为10 nM，30 nM，47 nM，84 nM，74 nM，140 nM和146 nM。
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T0070907 (T007), a potent and selective PPARγ inhibitor, can reduce α and β tubulin proteins in some cancer cell lines. T0070907是一种选择性的PPARγ抑制剂，IC50为1 nM，比作用于PPARα和PPARδ选择性高800倍以上。
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Ponatinib (AP24534)是一种新型有效的作用于Abl， PDGFRα， VEGFR2， FGFR1和Src的多靶点抑制剂， IC50分别为0.37 nM， 1.1 nM， 1.5 nM， 2.2 nM和5.4 nM。
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IWR-1-endo, an active endo form of IWR-1, is a small molecule inhibitor for Wnt/β-catenin signaling via the inhibition of tankyrase. IWR-1-endo是一种Wnt通路抑制剂，IC50为180 nM，诱导Axin2蛋白水平，且促进β-catenin磷酸化。
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FH535, a dual small-molecule inhibitor of Wnt/β-catenin signaling pathway and the peroxisome proliferator-activated receptor (PPAR), shows potent inhibition of various cancers. FH535能双重抑制Wnt/beta-catenin和PPAR信号通路。
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