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Efalizumab, a recombinant humanized monoclonal IgG1 antibody directed against a subunit (CD11a) of leukocyte function-associated antigen-1 (LFA-1), inhibits the T cell activation, migration and adhesion to keratinocytes.
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Etanercept, a TNFα receptor Fc fusion protein that binds to IgG1, is used for the treatment of rheumatic disease and psoriasis.
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Evolocumab (Repatha, AMG 145) is a fully human monoclonal antibody against PCSK9, significantly reduces low-density lipoprotein-cholesterol (LDL-C) levels.
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Gemtuzumab, a humanized anti-CD33 monoclonal antibody, is used to treat patients with previously untreated or recurrent acute myelogenous leukemia (AML).
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Golimumab is a fully human anti-TNF IgG1κ monoclonal antibody that acts principally by targeting and neutralizingTNF to prevent inflammation and destruction of cartilage and bone.
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