Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials.
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Phenytoin是一种失活的电压门控钠离子通道稳定剂。
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Lamotrigine是一种新型抗惊厥药剂，作用于人类血小板和大鼠脑突触体，抑制5-羟色胺(5-HT)吸收，IC50分别为240 μM和474 μM。
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Desloratadine是一种有效的人组胺H1受体拮抗剂，IC50为51nM.
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Chlorpheniramine是组胺H1受体拮抗剂，IC50为12 nM。
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Ciproxifan是高活性的H3受体拮抗剂，IC50为9.2 nM，对其它亚型受体的亲和力较低。
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