E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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Naringenin, a common dietary flavonoid abundantly present in fruits and vegetables, is believed to possess strong anti-proliferative properties and the ability to induce apoptosis in hepatoma cell lines.
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Urapidil HCl是Urapidil的盐酸盐形式，是α1-肾上腺素能受体拮抗剂和5-HT1A受体激动剂，pIC50分别为6.13和6.4。
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Escitalopram oxalate是选择性5羟色胺重吸收抑制剂（SSRI），Ki为0.89 nM。
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Sumatriptan succinate是5-HT1受体激动剂，可作用于偏头疼。
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Ziprasidone盐酸盐是5-HT和多巴胺受体拮抗剂，有抗精神病活性。
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