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NF-κB


NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.

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    3-MPPI是α1 配体。

    More

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    2-PMDQ是活性的， 选择性 α1 拮抗剂。

    More

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    2-MPMDQ是活性的， 选择性 α1 拮抗剂。也是σ2 配体。

    More

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    (S)-(+)-Niguldipine hydrochloride是α1 拮抗剂， L-type Ca2+ 通道阻断剂。

    More

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    More
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