Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience is recognized as a branch of biology.
A neuron is an electrically excitable cell that processes and transmits information through electrical and chemical signals. These signals between neurons occur via synapses, specialized connections with other cells. Neurons can connect to each other to form neural networks. Neurons are the core components of the brain and spinal cord of the central nervous system (CNS), and of the ganglia of the peripheral nervous system (PNS).
All neurons are electrically excitable, maintaining voltage gradients across their membranes by means of metabolically driven ion pumps, which combine with ion channels embedded in the membrane to generate intracellular-versus-extracellular concentration differences of ions such as sodium, potassium, chloride, and calcium. Changes in the cross-membrane voltage can alter the function of voltage-dependent ion channels. If the voltage changes by a large enough amount, an all-or-none electrochemical pulse called an action potential is generated, which travels rapidly along the cell's axon, and activates synaptic connections with other cells when it arrives.
TC-E 5006是γ-secretase调节剂,降低Aβ42的水平。
MoreSBHA是HDAC(Histone deacetylase)抑制剂。
MorePyroxamide是组蛋白去乙酰抑制剂HDAC (histone deacetylase)。
MoreNSC 3852是组蛋白脱乙酰酶抑制剂HDAC(histone deacetylase)。
MoreMRK 560是γ分泌酶(secretase) 抑制剂可以抑制淀粉样斑块沉积(amyloid plaque deposits)。
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