Endocrinology is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones.
The endocrine system consists of several glands, all in different parts of the body, that secrete hormones directly into the blood rather than into a duct system. Hormones have many different functions and modes of action; one hormone may have several effects on different target organs, and, conversely, one target organ may be affected by more than one hormone.
NSC 66811是MDM2 拮抗剂。 NSC 66811 disrupts MDM2-p53 interaction。
MoreJW 67是Wnt 通路抑制剂,诱导active β-catenin的降解。
MoreJW 74是Wnt 通路抑制剂。
MoreIWP 4是Wnt/β-catenin signaling的活性抑制剂。
MoreNutlin-3是一种有效的,选择性Mdm2(p53的环指依赖性泛素蛋白连接酶)拮抗剂,无细胞试验中IC50为90 nM;可稳定p53缺陷细胞中的p73。
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