The structure, function and dynamic behaviour of the cytoskeleton can be very different, depending on organism and cell type. Even within one cell the cytoskeleton can change through association with other proteins and the previous history of the network.
BV-6是一种SMAC模拟的cIAP和XIAP的双重抑制剂。
MoreYM155 (Sepantronium Bromide)是一种有效的survivin抑制剂,通过抑制Survivin启动子活性而发挥作用,IC50为0.54 nM;对SV40启动子活性抑制作用不显著,对Survivin与XIAP相互作用抑制效果微弱。Phase 1/2。
MoreBirinapant为二价Smac类似物,是XIAP和cIAP1的拮抗剂,Kd分别为45 nM和<1 nM。
MoreTriptolide是由中草药-雷公藤中提取的免疫抑制剂。
MorePF-3758309, a potent ATP-competitive inhibitor of PAK1 and PAK4, displays broad anti-tumor activity in cellular proliferation and apoptosis. PF-3758309是PAK4抑制剂,IC50为1.3 nM,能抑制HCT116,A549,M24met和别的肿瘤外植体模型。
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