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Pizotifen is an antagonist of muscarinic receptors and a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity.
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Tizanidine HCl is a skeletal muscle relaxant. It is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.
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Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA).
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Pralatrexate(Folotyn) is an inhibitor of DHFR (dihydrofolate reductase). Its IC50 is < 300 nM in some cell lines.
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Tamoxifen is a selective estrogen receptor (ER) modulator. Tamoxifen-induced apoptosis was associated with inhibition of cancerous inhibitor of protein phosphatase 2A (CIP2A) and phospho-Akt (p-Akt) in a dose-dependent manner.
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