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Methimazole(Tapazole, Northyx) is an antithyroid medicine. It is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
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Metolazone(Zaroxolyn) is an inhibitor of thiazide-sensitive Na+-Cl- cotransporter; antihypertensive; moderate "loop" diuretic.It is primarily used to treat congestive heart failure and high blood pressure.
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Gestodene is a progestogen hormonal contraceptive. Gestodene is a novel synthetic progestin--characterization of binding to receptor and serum proteins.
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Drospirenone is a ourth-generation and synthetic progestogen exhibiting antiandrogenic and antimineralocorticoid activity.
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Pizotifen is an antagonist of muscarinic receptors and a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity.
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