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Lactulose is a keto analogue of lactose, a disaccharide composed of galactose and fructose. It is a stimulator of health-promoting bacterium growth in the gastrointestinal tract, used to treat chronic constipation and hepatic encephalopathy.
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Tadalafil is a potent and selective inhibitor of PDE5A (Phosphodiesterase-5, PDE5) with an IC50 value of 1.8 nM.
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Pimobendan is a selective inhibitor of phosphodiesterase III(PDE3) with IC50 of 0.32 μM. Pimobendan is an inotropic agent with a dual mechanism of action: it increases myocardial contractility by increasing calcium sensitization to troponin C and it promotes vasodilatio.
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Methimazole(Tapazole, Northyx) is an antithyroid medicine. It is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
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Metolazone(Zaroxolyn) is an inhibitor of thiazide-sensitive Na+-Cl- cotransporter; antihypertensive; moderate "loop" diuretic.It is primarily used to treat congestive heart failure and high blood pressure.
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