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Ursodiol reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones. (IC50=0.22 μM). Ursodiol is a bile acid with significant colon chemopreventive activity.
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Nitrofurazone is antimicrobial.Nitrofural is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg).
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Lactulose is a keto analogue of lactose, a disaccharide composed of galactose and fructose. It is a stimulator of health-promoting bacterium growth in the gastrointestinal tract, used to treat chronic constipation and hepatic encephalopathy.
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Tadalafil is a potent and selective inhibitor of PDE5A (Phosphodiesterase-5, PDE5) with an IC50 value of 1.8 nM.
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Pimobendan is a selective inhibitor of phosphodiesterase III(PDE3) with IC50 of 0.32 μM. Pimobendan is an inotropic agent with a dual mechanism of action: it increases myocardial contractility by increasing calcium sensitization to troponin C and it promotes vasodilatio.
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