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Alendronate is an inhibitor of CD45RC and MMP. It is also a selective inhibitor of FDPS (farnesyl diphosphate synthase). Alendronate, a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis.
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Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.
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Chlorothiazide is one of the first in the thiazide class of diuretics. It is an inhibitor of carbonic anhydrase (IC50=3.8 mM) and is slightly less potent than acetazolamide (sc-214461). This compound has been shown to block reabsorption of sodium and chloride ions.
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Ursodiol reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones. (IC50=0.22 μM). Ursodiol is a bile acid with significant colon chemopreventive activity.
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Nitrofurazone is antimicrobial.Nitrofural is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg).
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