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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Glimepiride EI1190

    Glimepiride是Kir6 (KATP) 通道阻断剂。

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  • Gisadenafil besylate EI1187

    Gisadenafil besylate是活性的 PDE5 抑制剂， 口服有效。

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  • Gedunin EI1178

    Gedunin是Hsp90 抑制剂， 展现抗肿瘤抗疟活性。。

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  • GBR 12909 dihydrochloride EI1174

    GBR 12909 dihydrochloride是选择性 DA uptake inhibitor（摄取抑制剂）。 也是 σ 的配体。

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  • Ganaxolone EI1166

    Ganaxolone是活性的GABAA受体阳性变构的调节剂（positive allosteric modulator）。

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