In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
GNF 2是Bcr-Abl酪氨酸激酶的选择性变构抑制剂(allosteric inhibitor)。
MoreGlycyl-H 1152 dihydrochloride是Glycyl-H 1152 dihydrochloride is a selective Rho-kinase (ROCK) inhibitor.H 1152 dihydrochloride更加活性的类似物。
MoreGlimepiride是Kir6 (KATP) 通道阻断剂。
MoreGisadenafil besylate是活性的 PDE5 抑制剂, 口服有效。
MoreGedunin是Hsp90 抑制剂, 展现抗肿瘤抗疟活性。。
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