In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
H 1152 dihydrochloride是选择性 Rho-kinase (ROCK) 抑制剂。
MoreH2L 5765834是LPA1,3,5 拮抗剂。
MoreH2L5186303是活性的,选择性 LPA2 受体拮抗剂。
MoreGuvacine hydrochloride是特异性 GABA uptake inhibitor(摄取抑制剂)。
MoreGW 542573X是KCa2.1 离子通道选择性激动剂。
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