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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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  • Cucurbitacin I EY2197

    Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

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  • EAI045 EY2204

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  • Rhapontigenin EY2024

    A natural analog of resveratrol and an inhibitor of CYP1A1.

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  • FICZ EY2025

    FICZ(6-Formylindolo[3,2-b]carbazole)是芳香烃受体AHR配体，CYP1A1基因表达的有效诱导剂。

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