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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Anisomycin EY0446

    Anisomycin, a bacterial antibiotic, known as a peptidyl transferase inhibitor, induces apoptosis by activating several MAPKs and by inhibiting protein synthesis. Anisomycin是一种吡咯烷抗生素, 抑制蛋白质合成, 也是有效的SAPKs/JNKs激活剂。

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  • BI-D1870 EY0449

    BI-D1870是ATP竞争性S6核糖体抑制剂，对RSK1/2/3/4的IC50分别为31 nM/24 nM/18 nM/15 nM，比对MST2，GSK-3β，MARK3，CK1 和Aurora B的抑制性高10到100倍。

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  • Tubastatin A HCl EY0452

    Tubastatin A盐酸盐是HDAC6选择性抑制剂，IC50为15 nM，比对其它亚型的抑制性高1000倍（相对HDAC8是57倍）。

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  • Selumetinib EY0454

    Selumetinib (AZD6244)是一种高选择性的MEK1抑制剂，IC50为14 nM，也抑制ERK1/2磷酸化，IC50为10 nM，但对p38α， MKK6， EGFR， ErbB2， ERK2， B-Raf等没有抑制作用。

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  • Sodium Phenylbutyrate EY0455

    Sodium phenylbutyrate (NaPB), a derivative of the short-chain fatty acid butyrate, is a low-potency histone deacetylase inhibitor and originally approved for treatment of UCD. Sodium Phenylbutyrate是一种转录调节因子，通过调控HDAC活性来改变染色质结构从而发挥作用,是组蛋白脱乙酰酶（HDAC）抑制剂，IC50为1-5 uM。

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