COX
Cyclooxygenase (COX) is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. Pharmaceutical inhibition of COX can provide relief from the symptoms of inflammation and pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The two isozymes found in human are called COX-1 and COX-2 in the medical literature.
-
Celecoxib是环氧合酶-2(COX-2)选择性抑制剂，IC50为40 nM。
More
-
Indomethacin是非甾体抗炎化合物，可作用于发烧，肿胀和疼痛等。
More
-
Aspirin可作为止痛剂，也能通过抑制Cox-1起到抗炎作用。
More
-
Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.
More
-
Carprofen reduces inflammation by inhibition of COX-2 and other sources of inflammatory prostaglandins, does not interfere with COX-1 activity.
More
