Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials.
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Fexofenadine是第三代抗组胺药，用于治疗过敏症状，如花粉热，鼻塞和荨麻疹，抑制H1受体IC50值为246 nM。
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JNJ-7777120是一种选择性的组胺H4受体拮抗剂, Ki值为4 ±1 nM,比作用于其他组胺受体选择性高1000多倍。
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Nizatidine是一种组胺H2受体拮抗剂，作用于AChE，IC50为6.7 nM。
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A 803467是Nav1.8钠离子通道阻断剂，IC50为8 nM，比对Nav1.2，1.3，1.5和1.7的抑制性高100倍。
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Meclizine是H1组胺受体拮抗剂，可作用于晕动病。
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