EAATs(Glutamate transporters)
EAATs (Glutamate transporters, Excitatory amino-acid transporters,SLC1, GLT-1), being the most abundant subtype of glutamate transporter in the CNS, is a protein thatplays a key role in regulation of glutamate neurotransmission. and are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
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Carboplatin (卡铂) 能与DNA结合,干扰细胞修复。
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Temozolomide是一种DNA损伤诱导剂,烷化剂。
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Epirubicin hydrochloride是半合成的doxorubicin衍生物,能通过抑制拓扑异构酶起到抗肿瘤的作用。
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Fluorouracil (5-Fluoracil, 5-FU)是DNA/RNA合成抑制剂,通过抑制胸苷酸合成酶(TS)而干扰核苷酸合成。
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Fludarabine, a purine analog, is used in the treatment of hematological malignancies for the inhibition of STAT-1 activation and DNA synthesis. Fludarabine是一种STAT1活性抑制剂和DNA合成抑制剂。
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