p97


p97 knows also as VCP ( Cdc48 in yeast) is a hexameric ATPase of the AAA family which disassembles SNARE proteins after membrane fusion. It is involved in a fusion of homotypic membranes, protein degradation, and activation of membrane-bound transcription factors.
  • Gimeracil EY1629

    Gimeracil是二氢嘧啶脱氢酶(DPYD)抑制剂,能降解血液中的包含5-fluorouracil等的嘧啶。

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  • Glycyrrhizin EY1285

    Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.

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  • MNS EY1124

    MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂,抑制Syk, Src和p97, IC50分别为2.5 μM, 29.3 μM和1.7 μM。

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  • MK-8245 EY1125

    MK-8245是一种靶向作用于肝脏的stearoyl-CoA desaturase (SCD)(硬脂酰辅酶A去饱和酶)抑制剂,作用于人类SCD1时,IC50为1 nM,作用于大鼠和小鼠SCD1时,IC50为3 nM,具有抗糖尿病和抗高脂血症作用。

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  • Emodin EY1103

    Emodin是存在于多种植物根和树皮中的天然蒽醌,可通过调节不同的信号通路展现抗肿瘤细胞增殖的活性。

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