E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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Tropisetron是一种选择性5-HT3受体拮抗剂和α7-烟碱受体激动剂，作用于5-HT3受体，IC50为70.1±0.9 nM。
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Serotonin HCl是一种单胺类神经递质和内源性5-HT受体激动剂。
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Rizatriptan benzoate (苯甲酸利扎曲普坦; Maxalt) 是 5-HT1激动剂。
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Prucalopride是高亲和性5-HT4受体激动剂，对5-HT4a/4b的pKi分别为8.6/8.1，比对其它受体的亲和性高150倍。
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Prucalopride succinate是5-HT4受体选择高亲和性激动剂，对5-HT4a和5-HT4b的pKi值分别为8.6和8.1。
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