E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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Mosapride citrate是促胃肠动力化合物，是5HT4激动剂。
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VUF 10166是一种新型有效的，竞争性5-HT3A受体拮抗剂，Ki为0.04 nM，对5-HT3AB受体的亲和力显著下降。
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Naratriptan盐酸盐是5-HT1受体激动剂，可作用于偏头疼。
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Ondansetron盐酸盐是5-HT3受体拮抗剂，可作为化疗后止吐剂。
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Granisetron Hydrochloride是5-HT3受体拮抗剂，可作为化疗后止吐剂。
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