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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • GBR 12909 dihydrochloride EI1174

    GBR 12909 dihydrochloride是选择性 DA uptake inhibitor（摄取抑制剂）。 也是 σ 的配体。

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  • Ganaxolone EI1166

    Ganaxolone是活性的GABAA受体阳性变构的调节剂（positive allosteric modulator）。

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  • Gallein EI1163

    Gallein是 βγ signaling的抑制剂。

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  • Gadolinium chloride EI1157

    Gadolinium chloride是Stretch-activated calcium的通道阻断剂， calcium-sensing的受体激动剂。

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  • Gabapentin EI1156

    Gabapentin是抗惊厥剂， Increases brain GABA。

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