Wnt/beta-catenin
The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by binding a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine).
Catenin beta-1 also known as β-catenin is a protein that in humans is encoded by the CTNNB1 gene.
β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. Beta-catenin is widely expressed in many tissues.Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer.
Wnt signaling and the elevated level of beta-catenin in certain cell types is the maintenance of pluripotency.
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KY02111抑制Wnt信号，促进hPSCs分化为心肌细胞，可能对APC和GSK3β的下游起作用。
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LGK-974是特异的PORCN抑制剂，能抑制Wnt信号通路，IC50为0.4 nM。
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IWR-1-endo, an active endo form of IWR-1, is a small molecule inhibitor for Wnt/β-catenin signaling via the inhibition of tankyrase. IWR-1-endo是一种Wnt通路抑制剂，IC50为180 nM，诱导Axin2蛋白水平，且促进β-catenin磷酸化。
More
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FH535, a dual small-molecule inhibitor of Wnt/β-catenin signaling pathway and the peroxisome proliferator-activated receptor (PPAR), shows potent inhibition of various cancers. FH535能双重抑制Wnt/beta-catenin和PPAR信号通路。
More
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Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes. Kartogenin是针对软骨形成的小分子激动剂，促进软骨细胞分化（EC50为100nM），结合filamin A，并阻止其与转录因子CBFβ)的相互作用。
More
-
KY02111抑制Wnt信号，促进hPSCs分化为心肌细胞，可能对APC和GSK3β的下游起作用。
More
-
LGK-974是特异的PORCN抑制剂，能抑制Wnt信号通路，IC50为0.4 nM。
More
-
IWR-1-endo, an active endo form of IWR-1, is a small molecule inhibitor for Wnt/β-catenin signaling via the inhibition of tankyrase. IWR-1-endo是一种Wnt通路抑制剂，IC50为180 nM，诱导Axin2蛋白水平，且促进β-catenin磷酸化。
More
-
FH535, a dual small-molecule inhibitor of Wnt/β-catenin signaling pathway and the peroxisome proliferator-activated receptor (PPAR), shows potent inhibition of various cancers. FH535能双重抑制Wnt/beta-catenin和PPAR信号通路。
More
-
Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes. Kartogenin是针对软骨形成的小分子激动剂，促进软骨细胞分化（EC50为100nM），结合filamin A，并阻止其与转录因子CBFβ)的相互作用。
More
