Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials.
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Mizolastine是组胺H1受体拮抗剂，IC50为47 nM。
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Camostat Mesilate是一种胰蛋白酶样的蛋白酶抑制剂，抑制上皮细胞钠离子通道(ENaC)功能，IC50为50 nM，对胰蛋白酶、前列腺蛋白和蛋白裂解酶作用效果稍弱。
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Mianserin盐酸盐是H1受体反向激动剂，有抗抑郁活性。
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Lidocaine是组胺H1受体反向激动剂，IC50>32 μM。
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Zonisamide为1,2苯异恶唑衍生物，有抗癫痫活性。
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