Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials.
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Mianserin盐酸盐是H1受体反向激动剂，有抗抑郁活性。
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Lidocaine是组胺H1受体反向激动剂，IC50>32 μM。
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Zonisamide为1,2苯异恶唑衍生物，有抗癫痫活性。
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Phenytoin是一种失活的电压门控钠离子通道稳定剂。
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Lamotrigine是一种新型抗惊厥药剂，作用于人类血小板和大鼠脑突触体，抑制5-羟色胺(5-HT)吸收，IC50分别为240 μM和474 μM。
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