Proton Pump
The proton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms are based on conformational changes of the protein structure or on the Q cycle. In cell respiration, the proton pump uses energy to transport protons from the matrix of the mitochondrion to the inter-membrane space. The proton pump does not create energy, but forms a gradient that stores energy for later use.
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Hygromycin B是抗生素，对大多数细菌、真菌和一些真核生物有效。
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Dovitinib是多靶点RTK抑制剂，对FLT3和c-Kit的IC50分别为1 nM和2 nM，对FGFR1/3和VEGFR1-4的IC50为8-13 nM，对InsR，EGFR，c-Met，EphA2，Tie2和Dovitinib(CHIR-258; TKI258)是多靶点RTK抑制剂，对FLT3和c-Kit的IC50分别为1 nM和2 nM，对FGFR1/3和VEGFR1-4的IC50为8-13 nM，对InsR，EGFR，c-Met，EphA2，Tie2和IGFR抑制性较弱。
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FK866 (APO866, Daporinad)是一种有效的NAD抑制剂，因此可以抑制NAD依赖的烟酰胺转磷酸核糖基酶(NAMPT)的活性，IC50为0.09 nM。
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KY02111抑制Wnt信号，促进hPSCs分化为心肌细胞，可能对APC和GSK3β的下游起作用。
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